Pharmaceutical Cocrystal as a Viable Alternative to the Solid State Modification of Potential Drug Candidates: A Short Review
DOI:
https://doi.org/10.31305/rrijm2024.v04.n03.007Keywords:
Active Pharmaceutical ingredients, Polymorphic crystal, Crystal Engineering, Cocrystal, Supramolecular synthon, Cambridge Structural Database (CSD)Abstract
Majority of the active pharmaceutical ingredients (APIs) are marketed as solid and solubility and bioavailability etc. issues are also associated with the solid form of drug molecules. Thus, pharmaceutical inductries developed some techniques namely selection better polymorph, salt selection with biologically acceptable components. Polymorphic crystals of APIs and salt selection for non-ionisable APIs are very difficult to achieve. Crystal Engineering based cocrystallisation of APIs have been developed to address some of the issues related to the solid form of APIs. This short review highlights the recent achievement of the pharmaceutical cocrystal with improved physico-chemical properties.
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